refusal-of-treatment

start timer

ℹ️ This is the case information for the doctor.

Name

David Johnson

Age

67

Address

27 Willow Road, Manchester, M14 7EA

Social history

Smoking status: Ex-smoker.

Alcohol intake: Teetotal

Past history

2 unprovoked DVTs 15 years ago and 3 years ago

No other medical history on records

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Investigation results

No recent blood tests. Last monitoring for DOAC over 18 months ago.

Medication

Edoxaban 60 mg daily (blood thinner) – last prescribed 4 months ago. null.

No other regular medications.

No known drug allergies.

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Booking note

Patient has not had monitoring for DOAC (Edoxaban) for 18 months despite repeated requests. Medication supply reduced to 14 days pending blood test, but patient still did not attend. Stopped taking DOAC two months ago. Advised to book appointment with GP. (Pharmacist)

ℹ️ This is the information for the person role playing the patient.

Case overview

Name

David Johnson

Age

67

Address

27 Willow Road, Manchester, M14 7EA

Social history

Smoking status: Ex-smoker.

Alcohol intake: Teetotal

Past history

2 unprovoked DVTs 15 years ago and 3 years ago

No other medical history on records

‍

Medication

Edoxaban 60 mg daily (blood thinner) – last prescribed 4 months ago. null.

No other regular medications.

No known drug allergies.

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Opening statement

They told me to book an appointment about my blood thinner tablets, Doctor. I keep getting hassled for blood tests.

Information freely divulged

  • You have stopped taking your Edoxaban about two months ago because you got fed up with frequent calls and requests for blood tests.
  • The pharmacy team kept phoning and would only give two weeks’ supply, so after that ran out you just stopped.
  • You don’t mind taking the tablet itself, but really dislike blood tests and don’t want ongoing testing.
  • You’ve been taking the Edoxaban for about three years because of blood clots in your legs.
  • You are living alone, since your wife died five years ago.
  • You’re mostly managing independently, going out for a walk every day and participating in occasional social activities (church, Wednesday club).
  • You feel fine at the moment – no pain, swelling, chest pain, shortness of breath, or bleeding.
  • Main concern is whether you have to keep having blood tests and if the calls will stop.

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Information given on questioning

a) Symptom details & Problem presentation

  • You’ve never noticed any bleeding problems or problems with your kidneys.
  • You haven’t had any symptoms suggestive of another blood clot since stopping the medication.
  • Last blood test “over a year ago” was normal in your recollection.

b) Ideas

  • You understand you were put on these tablets for clots in the past.
  • You know the medication is to “thin the blood” but aren’t clear on why blood tests are needed if you feel well.
  • You feel you’re taking a calculated risk by stopping the tablet, but you’re not particularly worried, preferring “to take your chances” over frequent blood tests.
  • You are aware that having had clots before puts you at risk.

c) Concerns

  • Main concern is dislike and fear of needles/blood tests – you “never liked them”, it’s “a real big thing” for you.
  • You don’t want medication that “needs all these blood tests all the time.”
  • Not keen to be reminded by frequent calls.
  • You mention (if rapport is good) a slight fatalism about health, e.g., “I don’t want to live forever,” and mention that your mum had dementia and you worry about ending up like her.

d) Expectations

  • You had wanted to discuss whether you really need these blood tests, and if the pharmacy team can stop chasing you about them.
  • You are happy to take the tablet if you don’t have to keep getting blood tests; otherwise, you are happy to stop the medication and “take your chances.”
  • If the doctor insists on regular blood tests, you would prefer not to continue with the medication.
  • You would appreciate a clear decision about how this will be managed (preferably: minimal or no blood tests, prescription for the tablets, and no more hassle from pharmacy team).

e) Family history

  • No family history of blood clots or kidney disease.
  • Mum had dementia in old age.
  • Wife died five years ago of breast cancer.
  • Children not involved in care/given medical details.

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Behaviour

Initial demeanour:

  • Frustrated and a bit fed up about the hassle from the pharmacy/GP team over blood tests and annoyed by repeated calls.

Further instructions

  • Firm and resistant if pressed about blood tests: express strong aversion and anxiety about having them.
  • If the doctor is empathetic and makes an effort to understand your reasons, you become more relaxed and appreciative in tone.
  • Mildly fatalistic: express a pragmatic approach to health (“I’d rather take my chances”).
  • If the doctor insists you must have blood tests to get the tablets, you become resigned and accept you won’t take them – “I just don’t want to have the tests, so I won’t take them.”
  • If the doctor adds the medication back without pushing tests and agrees to reduce contact from the pharmacy, you are grateful and relieved (“Thank you, Doctor. That’s really helpful,” “You sound more reasonable than the last person.”)
  • If rapport is very good, you may briefly mention your fear of losing independence (reference to mum’s dementia, not wanting to prolong life at any cost).
  • If the doctor seems dismissive, impatient, or patronising, you become terse, defensive, and mention you’ve already explained yourself to lots of people.
  • If offered a compromise (blood tests much less often than before), politely but firmly decline.
  • Happy to discuss your social support and day-to-day life if asked with genuine interest.

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ℹ️ To mark data gathering & diagnosis select from the descriptors below.

Positive descriptors

Negative descriptors

Data gathering was systematic and targeted ensuring patient safety.

Initiates the conversation with open questions about recent contact and medication changes, then transitions to structured closed questions on bleeding, clot symptoms, and medication adherence.

Clarifies the patient’s understanding of anticoagulation use and ensures questions cover risk and systemic safety features.

Data gathering was incomplete, lacking structure and focus.

Does not clarify reasons for medication cessation or skips targeted questions around bleeding or thromboembolic risks.

Fails to use a logical progression, leading to missed safety-critical details (such as current or recent symptoms or adherence patterns).

Makes effective use of existing information and considers the wider context.

References information from previous consultations, including the pharmacy’s concerns, previous DVT episodes, and medication monitoring lapses.

Contextualises risk based on past events, prior blood results, and discusses living situation and supports to inform medical decision making.

Fails to use the information provided or understand the wider context.

Does not refer to previous DVT diagnoses or the long therapy gap noted in records.

Overlooks significance of medication history and patient’s social circumstances, missing an opportunity for a holistic approach.

A working diagnosis was reached using a structured, evidence-based approach.

Recognises David’s high ongoing risk for recurrence of VTE due to multiple unprovoked DVTs.

Structures questions and risk assessment logically to weigh the risks of cessation, bleeding, and appropriate need for ongoing anticoagulation.

Fails to systematically assess and recognise high levels of risk from non treatment.

Fails to recognise David’s high ongoing risk for recurrence of VTE due to multiple unprovoked DVTs.

Quesitoning is scattergun and lacks a logical pattern or focus.

Uses an understanding of probability based on prevalence, incidence, and natural history to aid decision-making.

Assesses that recurrence risk of VTE is high in patients with previous unprovoked episodes, underpinning advice on need for life-long anticoagulation.

Recognises lower probability of major new adverse effects as patient has taken Edoxaban for 3 years with no issues.

Choice of diagnosis and/or investigations does not reflect disease likelihood.

Fails to identify that stopping anticoagulation in this context carries significant risk of recurrence.

Overestimates risks of ongoing use or pursues investigations that are not clinically indicated.

Revises hypotheses as necessary in light of additional information.

Adjusts approach after learning about the real reason for non-adherence (blood test aversion, system frustration), and does not pursue unnecessary investigation for other causes of non-compliance or complicating medical issues.

Updates the plan and advice based on patient’s evolving responses regarding willingness to restart medication if blood monitoring can be minimised.

Rigid consulting with new information not adequately considered and integrated into the working diagnosis.

Does not modify their approach after David clarifies he will not attend for blood tests, or continues to insist on standard monitoring without personalising care.

Fails to reflect a patient-centred shift in risk management following new patient disclosures.

Information gathered placed the problem in its psychosocial context.

Explores David’s feelings about blood tests, previous negative experiences, anxieties, and beliefs about longevity, risk, and medical monitoring.

Elicits the impact of medication monitoring on patient’s quality of life, independence, and his support network since his wife’s death.

The social and psychological impact of the problem was not adequately determined.

Neglects to address fear or aversion to needles, impact on mental well-being, or attitudes to risk and preventive medicine.

Fails to recognise possible loneliness, social isolation, and their relevance to treatment adherence or engagement.

ℹ️ To mark clinical management & medical complexity select from the descriptors below.

Positive descriptors

Negative descriptors

Offers management options that are safe and appropriate.

Considers the full spectrum of management options: continuation of Edoxaban with monitoring, cautious restarting, or ongoing non-pharmacological prevention if the patient refuses monitoring.

Explains rationale for each option, including the possibility of life-long anticoagulation in unprovoked DVT; outlines limitations of alternative anticoagulants (e.g., Warfarin needing even more monitoring).

Fails to provide appropriate and/or safe management choices.

Omits discussing key risk/benefit choices or presents a single rigid option.

Provides inadequate explanation of available anticoagulant options or ignores monitoring requirements.

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Continuity of care is prioritised.

Arranges follow-up to check on medication adherence and wellbeing, and sets expectation for a structured review (e.g., annual review, earlier if concerns arise).

Recognises that the management of a chronic condition (such as long-term anticoagulation) requires regular touchpoints, even when patient is resistant to some interventions.

Ongoing care is uncoordinated.

Fails to arrange or suggest any future contact for clinical monitoring, side-effect review, or mental health follow-up.

Leaves responsibility solely with the patient, without planned active review or clear shared next steps.

Empowers self-care and independence.

Encourages and supports actions the patient can take to reduce VTE risk (mobility, hydration, recognising signs of VTE/bleeding).

Provides info leaflets or resources to support patient autonomy and understanding.

Management fails to foster self-care and patient involvement.

Does not equip the patient to notice or act upon important symptoms, making them reliant solely on medical intervention.

Makes decisions for the patient, rather than in partnership, and provides minimal advice about self-management.

Prescribes safely considering local and national guidance.

Reviews the necessity of safe prescribing: notes requirement for kidney function monitoring and highlights risk if no tests are performed.

Documents discussion, rationale for prescribing or not, and agrees a plan which is defensible and aware of the gaps in recommended practice.

Unsafe prescribing, ignoring best practice.

Prescribes Edoxaban or other anticoagulant unsafely without adequate monitoring, or safety-netting ignoring known risks.

Arranges appropriate follow-up.

Suggests a proactive plan for review (e.g., annual medication review, or sooner if symptoms emerge or patient is willing for monitoring).

Ensures the patient knows how to access care urgently if “red flag” symptoms develop.

Unclear or inadequate follow-up.

Leaves follow-up entirely open-ended or the patient uncertain about what happens next; does not prompt active review.

Fails to make arrangements for checking adherence, monitoring, or providing a future “touchpoint” to reconsider key decisions.

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Tailors management options responsively according to circumstances, priorities, and preferences.

Involves David in every step of the management decision, actively eliciting what would make treatment palatable.

Offers creative solutions, such as thinking about whether tests could be done less frequently, or exploring if anything would make tests more acceptable to him.

Management options fail to adequately consider patient preference and circumstance.

Insists on guideline-driven monitoring or medication regardless of the patient’s priorities.

Fails to ask open questions about what would help, or to explore alternatives based on the patient’s needs and values.

ℹ️ To mark relating to others select from the descriptors below.

Positive descriptors

Negative descriptors

Shows ability to communicate in a person-centred way

Clearly explains the reason for the call and the importance of discussing his anticoagulation, focusing on his individual experience with the medication and his feelings about repeated blood test requests.

Takes time to clarify David’s understanding, listens to his frustrations, and adapts pace and tone to maintain rapport.

Fails to communicate with David as an indiviidual

Provides factual information on Edoxaban and blood monitoring but fails to address David’s frustrations about being “hassled.”

Misses opportunities to engage David’s viewpoint, focusing instead on medication guidelines.

Treats patients fairly and with respect

Acknowledges David’s autonomy in deciding whether to take his medication or attend monitoring, and never pressures him or dismisses his choices.

Maintains a neutral, respectful tone, ensuring David feels comfortable expressing his boundaries.

Dismissive of concerns

Dismisses David’s concerns about blood tests or treats his reluctance as non-compliance.

Adopts a paternalistic, judgmental stance, implying there is only one correct choice and undermining David’s self-determination.

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Shows understanding of medical-legal principles and regulatory standards

Explains the need for monitoring in the context of treatment risks, David’s capacity and understanding, and supports informed shared decision-making.

Clearly explains the potential consequences and checks David can weigh them, showing respect for consent and autonomy.

Shows understanding of medical-legal principles and regulatory standards

Proceeds without confirming David’s comprehension of safety issues, risks, or alternatives.

Explores the patient’s agenda, health beliefs and preferences

Explores why David dislikes blood tests beyond simple dislike, seeking to understand his previous experiences, beliefs about health, and reluctance to medical monitoring.

Asks how blood test requirements affect his willingness to engage with treatment.

Shows little interest in the patients agenda and beliefs.

Accepts “I don’t want to have blood tests” at face value, relying on closed or leading questions.

Misses the opportunity to uncover deeper reasons, such as anxieties, previous trauma, or concerns about health system interactions.

Recognises what matters to the patient and works collaboratively to enhance patient care

Collaborates to find a solution tailored to what David values—minimal intrusion, independence, clarity about follow-up, and fewer reminders.

Acknowledges David’s priorities and negotiates a mutually acceptable follow-up plan, including his right to decline at any time.

Plans are untailored ignoring  patient preference

Suggests a standard plan without negotiation or adaptation; ignores cues about what matters to David in his day-to-day life.

Imposes generic follow-up as protocol, instead of tailoring to David’s needs.

Demonstrates flexibility of communication adapting to the patient and scenario

Shifts explanation style and consultation structure to match David’s needs, simplifying clinical language and giving options where possible.

Uses questions to explore David’s feelings, and changes approach if previous efforts do not elicit useful information.

Consults rigidly to a script

Sticks to a fixed, scripted approach; asks technical or repetitive questions despite a clear negative response.

Fails to adjust style based on David’s cues about pace, emotional state, or readiness to engage.

ℹ️ Insights from the examiner

📝 Section 1: Case Overview and Consultation Priorities

Case at a glance

This case involves a patient at high risk of venous thromboembolism (VTE) who has stopped taking edoxaban because he does not want the blood-test monitoring required for safe treatment.

The consultation explores the tension between:

  • Respecting the patient’s autonomy.
  • The clinician’s duty to prevent harm.
  • The risks of untreated or undertreated VTE.
  • The risks of continuing anticoagulation without appropriate monitoring.
  • Professional and medicolegal responsibilities.

The consultation should not focus only on persuading the patient to restart medication. The clinician must understand why monitoring is unacceptable, assess capacity, explain the risks of action and inaction, explore alternatives and agree the safest achievable plan.

 

GP trainee performance focus

A strong GP trainee should demonstrate that they can:

  • Explore the reason for stopping edoxaban without judgement.
  • Assess current VTE risk, bleeding risk and general health changes.
  • Understand the patient’s values, preferences and quality-of-life concerns.
  • Explain why monitoring is needed in plain language.
  • Assess decision-making capacity.
  • Respect a capable refusal while maintaining professional responsibility.
  • Explore practical alternatives to reduce the burden of monitoring.
  • Provide clear safety-netting for bleeding and recurrent VTE.
  • Document the decision and communicate with the wider team.

 

What this case is testing

  • Structured clinical assessment.
  • Exploration of adherence barriers.
  • Ethical reasoning in a real consultation.
  • Capacity assessment.
  • Risk communication.
  • Shared decision-making.
  • Negotiating practical alternatives.
  • Managing capable refusal.
  • Safety-netting.
  • Documentation and care coordination.

 

Patient priorities and concerns

The patient may be concerned about:

  • The inconvenience or “hassle” of blood tests.
  • Needle phobia or previous traumatic experiences.
  • The effect of monitoring on independence.
  • Feeling that treatment is prolonging life without improving quality of life.
  • The burden of regular appointments.
  • The possibility of bleeding.
  • The need to take medication indefinitely.
  • The effect of treatment on daily routine.

The clinician’s priorities are to:

  • Establish why he stopped edoxaban.
  • Assess current VTE and bleeding risks.
  • Check for changes in renal function, mobility or general health.
  • Understand his values and preferences.
  • Check understanding and decision-making capacity.
  • Explain the risks of taking and not taking anticoagulation.
  • Explore practical alternatives.
  • Agree monitoring and safety-netting arrangements.
  • Document the decision clearly.

 

Central challenge

The central challenge is to respect a capable refusal while ensuring that the patient understands the potential consequences.

The clinician needs to avoid:

  • Coercion.
  • Judgemental language.
  • Assuming refusal means lack of capacity.
  • Stopping the discussion as soon as the patient says no.
  • Continuing treatment without considering safe monitoring.
  • Ignoring the high risk of recurrent DVT or PE.

 

Must-not-miss issue or diagnosis

The must-not-miss issue is serious harm from either:

  • Stopping anticoagulation, increasing risk of recurrent DVT, pulmonary embolism or potentially fatal VTE.
  • Continuing anticoagulation without monitoring, increasing the risk of unsafe prescribing, renal impairment, unrecognised bleeding or delayed detection of side effects.

 

Red flags or high-risk features

High-risk features include:

  • New leg swelling or pain.
  • Sudden chest pain.
  • Breathlessness.
  • Coughing blood.
  • Fainting or severe weakness.
  • Unusual bruising.
  • Bleeding that does not stop.
  • Black stools or blood in the urine.
  • Vomiting blood.
  • Reduced mobility.
  • Recent illness or hospital admission.
  • Change in renal function or other relevant health factors.
  • New medication or general health change.

 

Common GP trainee pitfalls

  • Trying to persuade before understanding why the patient refuses monitoring.
  • Assuming refusal means lack of capacity.
  • Giving one-sided information about the risk of stopping treatment only.
  • Ignoring the risks of anticoagulation without monitoring.
  • Using coercive or judgemental language.
  • Failing to explore needle phobia, trauma, mood, bereavement, isolation or quality of life.
  • Not offering practical alternatives.
  • Not safety-netting for both bleeding and recurrent VTE.
  • Failing to document capacity, risks discussed and the agreed plan.
  • Withdrawing care because the patient declines the preferred option.

 

What good looks like

A strong consultation is respectful, structured and ethically transparent. The trainee explores the patient’s reasoning, explains risks clearly, assesses capacity, offers alternatives and keeps the relationship open even if the patient continues to refuse monitoring.

“It’s your decision, and I want to make absolutely sure you have all the facts to choose what’s best for you. My job is to help you weigh up the risks and benefits, and make choices that are as safe as possible.”

Learner checkpoint

Have I understood why the patient is refusing monitoring before trying to solve the problem?

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📝 Section 2: Patient-Centred Consultation and Data Gathering

Start with an open question

Use open, non-leading questions and allow the patient to explain without interruption.

“Can you tell me more about what makes blood tests difficult for you?”

Then signpost the consultation:

“I’d like to understand what makes the blood tests difficult, explain the risks of stopping the medication, and then see whether there is a safer option that fits better with your priorities.”

 

Time-efficient data gathering

Gather a clear, systematic and contextual history.

Ask:

  • When and why did the patient stop edoxaban?
  • Was the decision sudden or gradual?
  • Has he had any VTE symptoms since stopping?
  • Has he had leg swelling or pain?
  • Any chest pain or breathlessness?
  • Any bleeding or unusual bruising?
  • Any change in mobility?
  • Any recent illness or hospital admission?
  • Has his general health changed?
  • Has he started any new medication?
  • Has there been a change in renal function or other relevant health factors?

High-yield questions

 

Reason for stopping edoxaban

  • “What led you to stop taking it?”
  • “Was there a particular blood test or appointment that made you decide?”
  • “Was this something you had been thinking about for a while?”

 

Understanding of treatment and monitoring

  • “What do you understand the edoxaban is for?”
  • “What do you think the blood tests are checking?”
  • “Can you explain in your own words why blood tests are needed when taking this medicine?”

 

Practical barriers

Explore whether monitoring is difficult because of:

  • Transport.
  • Mobility.
  • Appointment burden.
  • Independence.
  • Daily routine.
  • Frequency of blood tests.
  • Difficulty attending healthcare settings.

 

Emotional and psychological barriers

Ask about:

  • Fear of needles.
  • Previous traumatic experiences.
  • Frustration with appointments.
  • Low mood.
  • Bereavement.
  • Social isolation.
  • Feeling that treatment is burdensome.
  • A belief that treatment is no longer worthwhile.

 

Clinical risk

Ask about:

  • Leg swelling or pain.
  • Chest pain.
  • Breathlessness.
  • Coughing blood.
  • Fainting or severe weakness.
  • Unusual bruising.
  • Bleeding that does not stop.
  • Black stools or blood in the urine.
  • Vomiting blood.
  • Recent illness, admission or change in mobility.

 

Functional, psychosocial or contextual assessment

Explore how anticoagulation and monitoring affect:

  • Daily routines.
  • Independence.
  • Transport.
  • Mobility.
  • Mood.
  • Social life.
  • Relationships.
  • Confidence in healthcare.
  • Perception of quality of life.

Ask about support from:

  • Family.
  • Friends.
  • Carers.
  • Pharmacy.
  • Community services.

 

Explore ideas, concerns and expectations

Clarify what the patient wants from the consultation.

“What would a good outcome from today’s discussion look like for you?”

Possible goals include:

  • Avoiding frequent blood tests.
  • Maintaining independence.
  • Reducing medication burden.
  • Understanding the risks of stopping treatment.
  • Finding a less burdensome way to monitor health.
  • Making a decision consistent with personal values.
  • Having a plan for future changes.

 

Recognise and respond to cues

Look for cues such as:

  • Frustration about appointments.
  • Fear of needles.
  • Previous trauma.
  • Bereavement.
  • Low mood.
  • Social isolation.
  • Feeling treatment is burdensome.
  • Saying he does not want to “live forever”.
  • Reluctance to discuss health concerns.
  • Feeling that clinicians are not listening.

Respond sensitively:

“It sounds as though this treatment has become a burden. Can you tell me more about what feels most difficult?”

If bereavement or low mood is mentioned, explore how this is affecting treatment decisions.

 

Useful consultation phrases

“I understand that the blood tests feel like a lot of hassle, and I want to understand what makes them particularly difficult for you.”

“The blood tests help us check that the medicine remains safe for you, particularly by checking how your kidneys are working and looking for problems that may not cause symptoms at first.”

“A refusal does not mean you lack capacity. I just need to check that you understand the key information and have been able to weigh it up.”

“This puts me in a difficult position. I want to respect your wishes, but I also need to keep you safe according to medical guidance. Could we explore whether there’s any way we could work together on this?”

“Even if it’s a ‘no’ for now, you can always change your mind, and we’re here to help if you do.”

 

Consultation flow and signposting

  1. Explore why edoxaban was stopped.
  2. Assess current VTE, bleeding and general health risks.
  3. Explore the practical and emotional impact of monitoring.
  4. Check understanding and capacity.
  5. Explain the risks of taking and not taking treatment.
  6. Discuss possible adjustments and alternatives.
  7. Agree the safest achievable plan.
  8. Provide safety-netting.
  9. Document and coordinate the decision.

 

Summarising and checking understanding

Summarise before moving into decisions:

“You stopped edoxaban because the blood-test monitoring feels too burdensome. I’ve also heard that this affects your independence and how worthwhile the treatment feels to you. We need to balance that against the risk of another clot, and also the risk of taking anticoagulation without the checks that keep it safe.”

Check:

  • Whether the summary is accurate.
  • Whether he understands the reason for anticoagulation.
  • Whether he understands the reason for monitoring.
  • Whether he can describe the risks of stopping.
  • Whether he can describe the risks of continuing without monitoring.
  • Whether he has questions before making a decision.

 

Data gathering self-check

Before agreeing a plan, the trainee should know:

  • Why the patient stopped edoxaban.
  • Whether there are current symptoms of VTE or bleeding.
  • Whether mobility, renal function or general health has changed.
  • Whether new medication or recent illness is relevant.
  • What monitoring means to the patient.
  • Whether barriers are practical, emotional, psychological or value-based.
  • Whether the patient understands the risks and benefits.
  • Whether he has capacity for this decision.
  • Whether he would consider any alternative monitoring arrangement.
  • What follow-up and safety-netting are acceptable.

Assessment domain mapping

 

Data gathering

  • Reason for stopping edoxaban.
  • Current VTE and bleeding symptoms.
  • Health, mobility, medication and renal-function context.
  • Practical and emotional barriers to monitoring.
  • Understanding, values and preferences.

 

Clinical management

  • Risk explanation for treatment and non-treatment.
  • Capacity assessment.
  • Practical alternatives to monitoring.
  • Safety-netting for bleeding and VTE.
  • Documentation and wider-team coordination.

 

Relating to others

  • Non-judgemental exploration.
  • Respect for autonomy.
  • Transparency about ethical uncertainty.
  • Maintaining care despite refusal.

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📝 Section 3: Clinical Reasoning and Personalised Management

Prioritised differential diagnosis or clinical reasoning

This is not primarily a diagnostic case. The clinical reasoning task is to balance:

  • High VTE risk.
  • Bleeding risk.
  • Safety of anticoagulation without monitoring.
  • Risks of stopping anticoagulation.
  • The patient’s values and preferences.
  • Decision-making capacity.
  • Practical and emotional barriers to monitoring.

The consultation should make the ethical reasoning explicit rather than presenting it as a simple compliance problem.

 

Clinical reasoning script

“There are risks on both sides. If you stop anticoagulation, there is a risk of another clot, including a DVT or pulmonary embolism. If you take anticoagulation without monitoring, we may miss changes such as kidney problems or bleeding risk that could make the medication unsafe. My role is to explain those risks clearly and help us find the safest plan you can accept.”

 

Red flags and risk assessment

Assess for symptoms that may suggest recurrent VTE or bleeding.

Urgent advice is needed if the patient develops:

  • New leg swelling or pain.
  • Sudden chest pain.
  • Breathlessness.
  • Coughing blood.
  • Fainting or severe weakness.
  • Unusual bruising.
  • Bleeding that does not stop.
  • Black stools or blood in the urine.
  • Vomiting blood.

Also consider whether risk has changed because of:

  • Reduced mobility.
  • Recent illness or hospital admission.
  • Change in renal function.
  • New medication.
  • General health deterioration.

 

Decision points

Key decisions include:

  • Does the patient have capacity to refuse monitoring and/or anticoagulation?
  • Does he understand the risk of recurrent DVT, PE and potentially fatal VTE?
  • Does he understand the risk of continuing anticoagulation without monitoring?
  • Is he willing to restart edoxaban with modified monitoring arrangements?
  • Are practical barriers modifiable?
  • Is specialist, pharmacy or senior advice needed?
  • What is the safest achievable plan if he continues to refuse?
  • How will the decision be documented and communicated?

 

Management priority

The management priority is to agree the safest achievable plan while respecting a capable refusal.

This means:

  • Explaining risks clearly.
  • Exploring alternatives.
  • Avoiding coercion.
  • Keeping care and communication open.
  • Documenting capacity and the agreed decision thoroughly.

Management options

 

1. Explain risks of not monitoring while taking anticoagulation

Explain the risks of continuing anticoagulation without monitoring, including:

  • Renal impairment.
  • Unrecognised bleeding.
  • Delayed detection of side effects.
  • Unsafe drug levels or treatment effects.
  • Failure to identify changes that affect prescribing safety.

 

2. Explain risks of stopping anticoagulation

Explain the risks of stopping, including:

  • Recurrent DVT.
  • Pulmonary embolism.
  • Potentially fatal VTE.
  • Increased risk associated with changes in mobility or general health.

The explanation should be balanced and proportionate.

 

3. Assess capacity

Assess whether the patient can:

  • Understand the relevant information.
  • Retain the information long enough to make a decision.
  • Weigh the risks and benefits.
  • Communicate his decision.

Do not assume refusal means lack of capacity.

 

4. Explore practical alternatives

Consider whether it is possible to:

  • Reduce practical barriers to appointments.
  • Arrange flexible or combined appointments.
  • Use community or home-based monitoring where available.
  • Coordinate blood tests with other healthcare visits.
  • Involve a pharmacist or wider team.
  • Provide reminders or transport support.
  • Arrange review with a familiar clinician.
  • Discuss fewer blood tests if clinically appropriate.

Example phrase:

“Would fewer blood tests help you feel better about monitoring?”

 

5. Agree a realistic monitoring plan if refusal continues

If the patient remains reluctant, agree the safest realistic plan. This may include:

  • At least an annual clinical review.
  • Blood tests if he becomes willing.
  • Clinical review without blood tests where appropriate.
  • Monitoring for symptoms of bleeding or recurrent VTE.
  • Keeping the discussion open for future reconsideration.

Do not imply that a clinically unsafe option is risk-free.

 

6. Seek wider support or advice

The plan may include discussion with:

  • Anticoagulation specialist.
  • Pharmacist.
  • Other clinicians involved in anticoagulation care.
  • Relevant specialists.
  • Community teams where appropriate.

Coordination helps avoid future conflict, duplication or confusion.

 

Personalised plan

A suitable plan should reflect:

  • The patient’s VTE risk.
  • His bleeding risk.
  • His reasons for refusing monitoring.
  • His capacity and informed preferences.
  • Practical circumstances.
  • Emotional wellbeing.
  • Feasibility of alternative monitoring.
  • Willingness to reconsider in the future.

The plan may include:

  • Further discussion with an anticoagulation specialist or pharmacist.
  • Practical adjustments to monitoring.
  • Minimum agreed clinical review.
  • Clear safety-netting.
  • Documentation and communication with the wider team.
  • Support for mood, bereavement or isolation.
  • Commitment to revisit the decision if his views change.

 

Shared decision-making

Affirm the patient’s right to make an informed choice.

“It’s your decision, and I want to make absolutely sure you have all the facts to choose what’s best for you.”

Explain that a capable adult can refuse treatment if they can understand, retain and weigh the relevant information and communicate their decision.

Discuss:

  • Risks of continuing treatment without monitoring.
  • Risks of stopping anticoagulation.
  • Possible benefits of alternative monitoring arrangements.
  • Option of reconsidering later.
  • Patient’s right to change his mind.

Safety-netting

The patient should seek urgent medical advice if he develops:

  • Unusual bruising.
  • Bleeding that does not stop.
  • Black stools or blood in the urine.
  • Vomiting blood.
  • New leg swelling or pain.
  • Sudden chest pain.
  • Breathlessness.
  • Coughing blood.
  • Fainting or severe weakness.

Example phrase:

“If you notice any unusual bruising, bleeding, leg swelling, chest pain or breathlessness, please call us or 111 straight away.”

Explain what to do in an emergency and ensure he knows how to access help outside normal practice hours.

 

Ethical, legal and safeguarding considerations

This case can be understood through four ethical principles:

  • Autonomy: respect the patient’s right to make an informed decision.
  • Beneficence: act in the patient’s best interests and promote wellbeing.
  • Non-maleficence: avoid preventable harm, including harm from untreated VTE or unsafe anticoagulation.
  • Justice: provide advice based on appropriate standards and guidance while ensuring safe and equitable care.

Be transparent about the dilemma:

“I wish there was a perfect solution that fitted the guidelines and your wishes exactly. Let’s work out together what feels right for you while keeping things as safe as possible.”

A capable refusal should be respected, but care should not be withdrawn.

 

Documentation points

Document clearly:

  • Reason the patient stopped edoxaban.
  • Information provided.
  • Risks of treatment and non-treatment.
  • Patient’s questions and concerns.
  • His understanding of the information.
  • Capacity assessment.
  • Ethical dilemma.
  • Options discussed.
  • Agreed decision.
  • Safety-netting.
  • Follow-up plan.
  • Any senior or specialist advice obtained.
  • Communication with the wider team.

 

Common unsafe management plans

Avoid:

  • Restarting or stopping treatment without exploring the reason for refusal.
  • Continuing anticoagulation without considering whether monitoring is safe.
  • Assuming the patient lacks capacity because he refuses.
  • Minimising the risk of recurrent VTE.
  • Ignoring bleeding risk and monitoring needs.
  • Using fear or coercion to force agreement.
  • Offering a plan that appears safer than it is.
  • Failing to safety-net for VTE and bleeding.
  • Not documenting capacity and reasoning.

 

Follow-up and coordination with other professionals

Coordinate the decision respectfully with:

  • Pharmacy.
  • Other clinicians involved in anticoagulation care.
  • Relevant specialists.
  • Community teams where appropriate.
  • Anticoagulation support services, if involved.

Arrange follow-up to review:

  • Whether the patient’s views have changed.
  • Any symptoms of VTE or bleeding.
  • Practical barriers to monitoring.
  • Mood, bereavement, isolation or quality-of-life concerns.
  • Whether further blood tests or monitoring have become acceptable.

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Learner checkpoint

Have I respected the patient’s autonomy while clearly documenting capacity, risks, safety-netting and the safest achievable plan?

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📝 Section 4: Key Guidance, Resources and References

Relevant guidance areas 

  • Ethical decision-making.
  • Venous thromboembolic disease management.
  • Mental capacity.
  • Anticoagulation and pharmacy support.
  • Local specialist advice and anticoagulation pathways.

 

NICE guidance

  • NICE NG158: Venous thromboembolic diseases: diagnosis, management and thrombophilia testing.

 

GMC, DVLA or safeguarding guidance

  • GMC Ethical Guidance.
  • Mental Capacity Act guidance.
  • NHS information about the Mental Capacity Act.

 

RCGP and SCA resources

  • RCGP SCA Toolkit.

 

Patient information websites

  • NHS information about the Mental Capacity Act.

 

Professional and local resources mentioned

  • Anticoagulation and pharmacy support services.
  • Local specialist advice and anticoagulation pathways.

 

Key principles to remember

  • Explore the reasons for refusal before offering solutions.
  • Do not assume refusal means lack of capacity.
  • Check that the patient understands, retains and weighs the relevant information.
  • Explain the risks of both continuing and stopping treatment.
  • Be transparent about the ethical dilemma.
  • Respect a capable refusal while keeping communication open.
  • Explore practical adjustments to monitoring.
  • Provide clear safety-netting for bleeding and recurrent VTE.
  • Consider bereavement, low mood, isolation and quality of life.
  • Document the discussion, capacity assessment and agreed decision thoroughly.
  • Coordinate the plan with the wider healthcare team.
  • Flexibility, partnership and explicit ethical reasoning are central to a high-quality consultation.

 

Transferable learning for future cases

When a patient refuses monitoring or treatment:

  • Start by understanding the refusal, not challenging it.
  • Separate practical barriers from values-based refusal.
  • Assess capacity for the specific decision.
  • Explain risks of both action and inaction.
  • Offer realistic alternatives without pretending they remove all risk.
  • Respect a capable refusal while maintaining follow-up and safety-netting.
  • Document the reasoning clearly.

 

Supervisor or examiner lens

A supervisor or examiner is likely to look for:

  • Non-judgemental exploration of adherence barriers.
  • Balanced explanation of VTE and bleeding risks.
  • Explicit capacity assessment.
  • Respect for capable refusal.
  • Ethical reasoning made visible.
  • Practical negotiation around monitoring.
  • Clear safety-netting.
  • Thorough documentation and team communication.

Final learner takeaway

A capable refusal is not a failed consultation: explore, inform, assess capacity, negotiate what is safe, document clearly and keep the door open.

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Authoring credit:

Clinitalk team