Weight loss and tremor

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ℹ️ This is the case information for the doctor.

Name

Claire Miller

Age

47

Address

14 Sweeny Road

Social history

Household: Lives with her husband, three children (two teenagers and an adult daughter), and young granddaughter. Busy, supportive family life—significant focus on looking after her granddaughter.

Occupation: Part-time care assistant;

Smoking: Non-smoker.

Alcohol: Rarely drinks

Past history

Depression (diagnosed 4 years ago; generally stable)

Hypertension (diagnosed 5 years ago; well controlled on medication)

Investigation results

FBC: Normal

U&E: Normal

LFTs: Normal

TSH: <0.01

Free T4: 49 (Normal range: 10–20)

Pulse: 94, regular

BP: 130/78

Medication

Amlodipine 5mg daily

No known drug allergies

Booking note

Last entry in records, 2 weeks ago, seen with increase in loose stools, weight loss, tremor, difficulty sleeping and palpitations,

ℹ️ This is the information for the person role playing the patient.

Case overview

Name

Claire Miller

Age

47

Address

14 Sweeny Road

Social history

Household: Lives with her husband, three children (two teenagers and an adult daughter), and young granddaughter. Busy, supportive family life—significant focus on looking after her granddaughter.

Occupation: Part-time care assistant;

Smoking: Non-smoker.

Alcohol: Rarely drinks

Past history

Depression (diagnosed 4 years ago; generally stable)

Hypertension (diagnosed 5 years ago; well controlled on medication)

Medication

Amlodipine 5mg daily

No known drug allergies

Opening statement

I've come to get my blood results. I've really not been feeling right, so I'm hoping you can tell me what's wrong with me.

Information freely divulged

Symptoms

"I just feel worn out and knackered, it's been going on for a couple of months now."

"I'm eating and eating but still losing weight—about 5 or 6 kilos."

"People have started commenting I look thinner, even though I'm not trying to lose weight."

"My heart feels like it's racing sometimes, going much more quickly than it ever used to."

"I’m probably going to the toilet more often—the stools are looser."

Impact

"Coping with everyday has been harder as I feel more tired than normal."

Information given on questioning

Symptom Clarification

  • No sickness or vomiting.
  • No visual problems, eye irritation, or double vision (unless specifically asked in detail; slight mention of eyes feeling "a bit sensitive" if probed).
  • No swelling or pain in the neck.
  • Sleep has been poor—trouble getting to sleep and waking up feeling wired.
  • "I haven't noticed any new lumps on my neck."
  • "Periods have been a bit irregular lately, but I thought it was just my age—I've missed a few recently."

Ideas

  • Something serious is going on, I'm worried it is serious.

Concerns

  • "I'm quite worried about the weight loss and the bowels. My dad had bowel cancer and died after getting similar symptoms. It's been playing on my mind."
  • "I don't want something serious like cancer and I don’t want my kids to go through that again."

Expectations

  • "I'd like to know exactly what's wrong and if it can be sorted out quickly."
  • "If I need any more tests, I’d like those done soon. I just want to get better."
  • "I'm anxious about needing an operation—my aunt had an op on her neck for her thyroid."
  • "I’d like some medication to help, if possible—I’m struggling to cope at the moment."

Family History

  • Father: Died from bowel cancer (diagnosed after weight loss/change in bowels).
  • Aunt: Thyroid condition, had an operation on her neck (presume partial thyroidectomy or similar).
  • "Family life is busy, I help with the kids and look after my granddaughter."

Behaviour

Initial Presentation: Claire comes across as tired, worried, and a bit anxious but open and cooperative. She’s eager for answers, somewhat preoccupied by her symptoms and her father's cancer history.

If doctor is empathetic and takes her concerns seriously: She becomes more calm and reassured, trusts the process, accepts explanations, and is keen to follow through with management plans.

If the doctor is dismissive or vague: Anxiety and frustration increase. She becomes more insistent and possibly emotional about her worries (especially cancer).

If thyroid cancer is mentioned: She looks worried and asks directly about the risk, referencing her father’s cancer and her aunt’s thyroid operation.

If medication is offered (especially beta blocker): She accepts it if the doctor explains the benefits for her symptoms and reassures her regarding safety.

If referred to hospital/endocrinology: Claire is understanding but anxious about waiting too long and asks about how she will manage symptoms in the meantime.

If anti-thyroid drugs are discussed/offered: She is keen to start something to help her feel better but wants to know about side effects and what to expect.

If ultrasound or further blood tests are suggested: She readily agrees, showing willingness to cooperate with further investigations if it will rule out anything serious.

Reflection and Rationale

  • Focus: Claire is an engaged and receptive patient whose main anxieties stem from a family history of cancer and distressing symptoms. She has clear ideas, concerns, and expectations.
  • Behavioural cues are driven mainly by worry and a desire for a clear, actionable plan.
  • Symptomatology is comprehensive for uncontrolled hyperthyroidism; rapport is essential for her to reveal the extent of her concerns and expectations, especially regarding family history and anxiety about cancer/operations.
  • Her behaviour should help the candidate demonstrate patient-centredness and safety-netting, particularly around management plans and reassurance regarding malignancy risk.

ℹ️ To mark data gathering & diagnosis select from the descriptors below.

Positive descriptors

Negative descriptors

Makes effective use of existing information and considers the wider context.

  • Integrates recent consultation notes and abnormal thyroid results with details from Claire’s medical and social history.
  • Considers the impact of symptoms on family, work, and wellbeing.

Fails to use the information provided or understand the wider context.

  • Overlooks key background notes (e.g., previous documentation of symptoms, relevant bloods).
  • Neglects to explore the effect on daily life or family responsibilities, and fails to recognise Claire’s heightened anxiety due to her father's history.

The presence or absence of relevant red flags was established.

  • Specifically inquires about weight loss, change in bowel habit, vomiting, neck lumps, and family history of bowel cancer to exclude serious pathology.
  • Asks about symptoms indicative of thyroid eye disease (e.g., eye discomfort, double vision) and features of thyroid storm (fever, agitation).

Fails to assess key information necessary to determine risk.

  • Does not explore cancer red flags or omits clarification about neck masses or family history.
  • Misses targeted questioning on thyroid eye complications and the possibility of severe thyrotoxicosis.

Information gathered placed the problem in its psychosocial context.

  • Explores how symptoms and anxiety are affecting Claire’s mood, ability to care for family, and her function at work.
  • Discusses her health beliefs and fears related to her father’s experience of cancer.

The social and psychological impact of the problem was not adequately determined.

  • Does not assess how symptoms influence home or work life, or skips discussion of mood, anxiety, or coping.
  • Fails to discuss or respond to the emotional impact of her father’s death.

A working diagnosis was reached using a structured, evidence-based approach.

  • Gathers sufficient history and makes a clear diagnosis of hyperthyroidism, with logical links between symptoms, abnormal TFTs, and absence of other causes.
  • Connects probability of disease with her demographic (female, middle-aged), symptom profile, and investigation findings.

The evidence collected was inadequate to support the conclusions reached.

  • Draws a diagnostic conclusion without sufficient or appropriate history, or fails to use investigation results to narrow down likely causes.
  • Does not use the demographic or natural history to underpin the diagnosis.

Revises hypotheses as necessary in light of additional information.

  • Adjusts early consideration of malignancy in light of biochemical evidence and reassures appropriately.
  • Re-checks for thyroid eye or cardiac symptoms once thyroid dysfunction is revealed, and safety nets for any rapid deterioration.

Rigid consulting with new information not adequately considered and integrated into the working diagnosis.

  • Ignores new information from blood results or patient cues, sticking to initial differentials such as cancer despite evidence pointing to hyperthyroidism.
  • Does not adapt the diagnostic approach as evidence accumulates.

Uses an understanding of probability based on prevalence, incidence, and natural history to aid decision-making.

  • Recognises that hyperthyroidism is common in women of Claire’s age, especially with her symptoms and biochemistry, and explains other causes are less likely.
  • Weighs cancer risk as very low given lack of localising features, and clarifies this against her family history.

Choice of diagnosis and/or investigations does not reflect disease likelihood.

  • Pursues unlikely diagnoses without supporting evidence or misrepresents risk (e.g., focuses excessively on bowel cancer based on family history alone).
  • Fails to prioritise thyroid disease in light of symptoms and abnormal blood results.

ℹ️ To mark clinical management & medical complexity select from the descriptors below.

Positive descriptors

Negative descriptors

Offers management options that are safe and appropriate

  • Offers to start a beta blocker for symptomatic relief of tremor and palpitations.
  • Provides a safety-net for potential deterioration (thyroid storm, new severe symptoms).

Fails to provide appropriate and/or safe management choices

  • Neglects the need for symptomatic relief.
  • Fails to safety-net for acutely worsening symptoms or complications.
  • Starts specialist treatment ignoring gui

Refers appropriately, being mindful of resource

  • Refers to endocrinology in line with guidelines, recognising the urgency due to very abnormal results and symptoms.
  • Considers waiting times and uses Advice & Guidance or urgent communication where local waits are long or symptoms severe.

Sends patients for specialist input unnecessarily, or omits essential referrals

  • Only makes an open or routine referral, without consideration of symptom severity or risk if local waits are prolonged.
  • Delays or omits essential specialist input in managing severe hyperthyroidism.

Prescribes safely considering local and national guidance

  • If proposing carbimazole, discusses need for baseline FBC and LFTs, counselling about neutropenia (sore throat/infection), and pregnancy avoidance.
  • Avoids unsafe options (e.g., NSAIDs, inappropriate drugs).

Unsafe prescribing ignoring best practice

  • Prescribes without recognising need for baseline safety bloods or patient information.
  • Fails to discuss potential important side effects or interactions.
  • Suggests inappropriate or unsafe treatments.

Arranges appropriate follow-up

  • Provides clear, timely follow-up arrangements—short interval review for symptoms and repeat bloods.
  • Specifies what symptoms need urgent reassessment (deterioration, eye pain, fever, confusion).
  • Ensures continuity with primary care and specialty in light of possible long waits.

Unclear or inadequate follow-up

  • Leaves patient uncertain about next steps.
  • Lacks clear plan for monitoring, symptom review, or practical arrangements for urgent review.

Practises holistically, promoting health, and safeguarding

  • Considers the impact of her illness on mental health and family responsibilities, checking if extra support is needed.
  • Assesses risk to herself or others if she remains unwell or deteriorates.
  • Offers support resources or signposts (e.g., thyroid disease information, support groups).

Fails to safeguard patient welfare

  • Ignores mental health or psychosocial consequences.
  • Treats laboratory result in isolation, neglecting risk to patient’s wellbeing or family function.

Manages uncertainty, including that experienced by the patient

  • Explains causes of hyperthyroidism in accessible language, addresses rare but concerning differentials (cancer), and reassures about prognosis.
  • Structure management when referral delays are possible, discusses interim safety and what to expect.

Struggles with uncertainty, leading to inconsistent decisions

  • Causes unnecessary alarm about rare causes without reassurance or context.
  • Does not provide a plan for what could happen if symptoms worsen before specialist review.

ℹ️ To mark relating to others select from the descriptors below.

Positive descriptors

Negative descriptors

Shows ability to communicate in a person-centred way:

  • Establishes rapport, acknowledges Claire’s fatigue and anxiety, especially regarding weight loss and her family history.
  • Adapts explanations, checking clarity when using technical terms (e.g. “overactive thyroid”), and reviews Claire’s understanding.

Communication is doctor-centred and lacks empathy:

  • Focuses on investigation results or uses medical jargon (“autoimmune,” “endocrinologist,” “hyperthyroidism”) without checking for comprehension.
  • Misses opportunities to respond to emotional cues or validate Claire’s specific fears.

Treats patients fairly and with respect:

  • Shows respect for Claire’s concerns about cancer and her recent experiences with illness in her family.
  • Acknowledges her role as a carer, validating her responsibilities and busy family life.

Decisions fail to prioritise the patient’s rights and interests:

  • Fails to appreciate how Claire’s background and beliefs (e.g., fear due to family cancer history) shape her concerns and expectations.
  • Gives generic advice without showing appreciation for Claire’s individuality or circumstances.

Explores the patient’s agenda, health beliefs and preferences:

  • Asks about Claire’s ideas, what’s been worrying her, and how she thinks the symptoms are linked.
  • Checks her expectations and priorities, including concerns about needing an operation or cancer.

Fails to recognise the patient’s agenda and impact of the problem:

  • Does not probe Claire’s underlying fears (particularly regarding cancer and operations).
  • Offers explanations about thyroid disease without connecting them to her experiences or beliefs.

The patients agenda was understood:

  • Elicits Claire’s specific worries about cancer and her hopes for clear answers and effective treatment.
  • Responds directly to her reference to her late father’s illness and connects management to her current needs.

The patients agenda was not well explored:

  • Fails to clarify or respond to Claire’s fear that her symptoms might represent cancer, missing her key concern.
  • Does not check what Claire wants from the consultation or her understanding of possible management strategies.

Demonstrates flexibility of communication adapting to the patient and scenario:

  • Adjusts explanation style for Claire’s level of understanding, avoiding jargon or clarifying terms as needed.
  • Alters approach in response to non-verbal or verbal cues, like distress when cancer is mentioned.

Consults rigidly, providing generic explanations and management plans:

  • Uses technical language (“autoimmune,” “endocrinologist”) even when Claire appears confused or anxious.
  • Does not pause or check Claire’s understanding when she signals worry or hesitation.

The language and content was appropriate for the patients level of understanding:

  • Explains technical topics (e.g., thyroid function, specialist roles) in accessible terms and pauses to check if Claire needs clarification.
  • Uses analogies or tailored explanations to match Claire’s health literacy.

Questions were not tailored to the patients level of understanding:

  • Uses complex terms without breaking them down when Claire seems confused or anxious.
  • Information is either overly simplistic or too detailed, without adapting language to Claire’s needs.

ℹ️ Insights from the examiner

1. Time Efficient Data Gathering

  1. Be Efficient and Fluent: While it is important to gather the story and symptoms, aim for a smooth and purposeful approach. Avoid making the consultation feel like a clerking exercise—focus on what is most relevant at each stage.
  2. Cover Key Symptoms: Make sure you ask specifically about all relevant symptoms, including any that could have diagnostic significance, such as eye symptoms in hyperthyroidism.
  3. Clarify Results: When discussing test results, be specific. Don’t just say “most are normal”; mention which ones have been checked and their outcomes, to provide clarity and reassurance.
  4. Explore Patient’s Perspective: Ask questions to fully understand the patient’s ideas, concerns, and expectations regarding their symptoms and diagnosis. Dig deeper into their understanding of the potential condition.
  5. Summarise Clearly: Use summaries, but do so smoothly and as part of a natural conversation rather than a checklist.

References:
NICE NG145, recommendations 1.2.3–1.2.8 (Assessment)

2. Clinical Management & Medical Complexity

  1. Actively Plan Management: In follow-up cases where the diagnosis is already known, focus prominently on the management options and safety. Be prepared to discuss initiating treatment if the patient is symptomatic (e.g., consider starting carbimazole) and clearly explain your reasoning.
  2. Explain Treatments Properly: When you mention medication (e.g., carbimazole, beta blockers), briefly explain what these are, their purpose, and possible side effects or monitoring needs.
  3. Discuss Safety Netting: Discuss what symptoms to look out for (e.g., eye symptoms, infection due to carbimazole), what to do if they develop, and clear follow-up plans (e.g., blood tests, ultrasound, checking thyroid antibodies).
  4. Be Proactive: Where appropriate, mention how you’d manage delays or waiting times for specialist input (for example, by seeking immediate advice from an endocrinologist or via Advice & Guidance).
  5. Consider the Future: Briefly outline possible future steps, such as what happens if initial treatments don’t work (e.g., possibility of surgery or radioactive iodine treatment).

3. Relating to Others

  1. Show Empathy: Respond to significant patient concerns or emotional moments (e.g., bereavement, family worries). Frame health positively. It does look like you have a problem with your thyroid, the good news is there is very effective treatment available.
  2. Avoid Jargon: Use plain language, and if you must use terms like “autoimmune” or “beta blocker,” always explain them in simple terms.
  3. Share Decisions: Involve the patient in management planning and check their understanding regularly. Ask for their preferences and concerns at key decision points.
  4. Be Specific About Risks/Next Steps: Don’t be vague; spell out what will happen next, what to watch for, and how the patient will be supported along the way.

4. Differential

NICE guidance on differentials includes:

  1. Graves’ disease (most common, especially in women <50, often with eye signs)
  2. Toxic multinodular goitre
  3. Toxic adenoma
  4. Subacute (de Quervain’s) thyroiditis
  5. Drug-induced (amiodarone, lithium)
  6. Ectopic (rare)
  7. Thyroid malignancy (rare)

5. Impact

  • Specifically ask about the effect on mental health and day-to-day function. NICE stresses a holistic approach.
  • “How are these symptoms affecting your work, family or mood?”

6. Options

NICE NG145 recommends:

  1. Referral to endocrinology (urgently if severe symptoms, eye involvement, or suspected pregnancy)
  2. Symptom control: Start a beta blocker (propranolol preferred, unless contraindicated)
  3. Antithyroid drugs (e.g. carbimazole): Can be initiated in primary care under specialist guidance, hospital out patient clinc waits may be too long.
  4. Arrange thyroid antibody testing if available, to help clarify etiology (especially if Graves' suspected)
  5. Arrange thyroid ultrasound if there is a thyroid nodule or concern about malignancy
  6. Further bloods: Repeat TFTs within a few weeks to monitor, plus baseline FBC/LFTs if starting carbimazole
  7. Safety net for complications: e.g., thyroid crisis, cardiac arrhythmia, worsening mental state, eye symptoms
  8. Provide written information and signpost support resources (British Thyroid Foundation, NHS/NICE)

7. Understanding

  • Check Claire’s understanding at each stage: “What questions do you have?”
  • Confirm she feels supported and has a plan.

Further Reading: